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KMID : 0381020110440060498
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Korean Journal of Nutrition
2011 Volume.44 No. 6 p.498 ~ p.506
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Relationship among Plasma Homocysteine, Folate, Vitamin and Nutrient Intake and Neurocognitive Function in the Elderly
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Kim Hee-Jung
Kim Hye-Sook
Kim Ki-Nam
Kim Ggot-Pin
Son Jung-In
Kim Seong-Yoon
Chang Nam-Soo
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Abstract
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This study examined the relationship among plasma homocysteine, folate, and vitamin levels and neurocognitive function in 118 community-dwelling elderly subjects (mean age, years). The Mini-Mental State Examination (MMSE-KC) was used to screen and assess neurocognitive function in the participants. Dietary intake data including the use of dietary supplements were obtained using the 24-hour recall method by well-trained interviewers. Plasma folate and vitamin concentrations were analyzed by radioimmunoassay, and homocysteine was assessed by a high performance liquid chromatography-fluorescence method. The proportions of participants with suboptimal levels of plasma folate (< 3 ng/mL), vitamin (< 221 pmol/mL), and homocysteine (> ) were 16.1%, 5.9%, and 21.2%, respectively. A multiple regression analysis showed that plasma homocysteine was negatively associated with plasma folate and vitamin levels. The MMSE-KC test scores were significantly associated with plasma homocysteine and folate, but not with vitamin , after adjusting for age, gender, body mass index, living with spouse, education, current smoking, energy intake, and chronic diseases such as hypertension, diabetes, thyroid disease, dyslipidemia, stroke, and cardiovascular disease. A general linear model adjusted for covariates revealed that MMSE-KC test scores increased from the lowest to the highest quartiles of vitamin , vitamin , vitamin , vitamin , and vitamin C intake (p for trend = 0.012, 0.039, 0.014, 0.046, 0.026, respectively). These results indicate that the problem of folate inadequacy and hyperhomocysteinemia are highly prevalent among community-dwelling elderly people and that dietary intake of the B vitamins and vitamin C is positively associated with cognitive function scores.
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KEYWORD
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homocysteine, folate, vitamin , cognitive function, elderly
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